RNA Details
Disease Name
proliferative diabetic retinopathy
Tissue
eye
RNA Symbol
mir-34a
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
dual-lucimmunofluorescenceerase reporter assay; immunofluorescence; etc.
Target
LGR4
Pathway
NA
PubMed ID
Title
LGR4 Is a Direct Target of MicroRNA-34a and Modulates the Proliferation and Migration of Retinal Pigment Epithelial ARPE-19 Cells
Year
2016
Function
"Mir-34a gene expression upregulation inhibits arpe-19 cell proliferation, migration and adhesion partly by suppressing lgr4 expression. These results substantiate earlier indications that both mir-34a and lgr4 are potential drug targets to prevent fibrosis in a clinical setting."